Stabilization of GABA<sub>A</sub>R synaptic structure by IP<sub>3</sub>-induced calcium release

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Calcium-induced calcium release

How are calcium levels increased within cells? Increases in intracellular calcium arise through either calcium influx across the plasma membrane or release from intracellular calcium stores, which is usually either the endoplasmic reticulum (ER) or, in muscle, the sarcoplasmic reticulum (SR). Release of calcium from the ER/SR is activated by a variety of second messengers, such as inositol 1,4,...

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Calcium-induced release of calcium

FABIATO, ALEXANDRE. Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. Am. J. Physiol. 245 (Cell Physiol. 14): CLC14, 1983.-The hypothesis of a Ca2+-induced Ca2+ release (CICR) from the sarcoplasmic reticulum (SR) is supported by experiments done in skinned cardiac cells (sarcolemma removed by microdissection). According to this hypothesis, the transsarcolemmal Ca2+ inf...

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Calcium-induced release of calcium

FABIATO, ALEXANDRE. Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. Am. J. Physiol. 245 (Cell Physiol. 14): CLC14, 1983.-The hypothesis of a Ca2+-induced Ca2+ release (CICR) from the sarcoplasmic reticulum (SR) is supported by experiments done in skinned cardiac cells (sarcolemma removed by microdissection). According to this hypothesis, the transsarcolemmal Ca2+ inf...

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Calcium-induced release of calcium

FABIATO, ALEXANDRE. Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. Am. J. Physiol. 245 (Cell Physiol. 14): CLC14, 1983.-The hypothesis of a Ca2+-induced Ca2+ release (CICR) from the sarcoplasmic reticulum (SR) is supported by experiments done in skinned cardiac cells (sarcolemma removed by microdissection). According to this hypothesis, the transsarcolemmal Ca2+ inf...

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LIM domain only 4 (LMO4) regulates calcium-induced calcium release and synaptic plasticity in the hippocampus.

The LIM domain only 4 (LMO4) transcription cofactor activates gene expression in neurons and regulates key aspects of network formation, but the mechanisms are poorly understood. Here, we show that LMO4 positively regulates ryanodine receptor type 2 (RyR2) expression, thereby suggesting that LMO4 regulates calcium-induced calcium release (CICR) in central neurons. We found that CICR modulation ...

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ژورنال

عنوان ژورنال: Folia Pharmacologica Japonica

سال: 2016

ISSN: 0015-5691,1347-8397

DOI: 10.1254/fpj.147.184